GLOBE score

The GLOBE score is an internationally relevant and validated risk assessment tool, able to accurately stratify PBC patients to high and low risk.

Patients with a GLOBE score corresponding with an estimated transplant-free survival comparable with an age- and sex-matched population are at low risk for future adverse events and patients with a GLOBE score corresponding with a transplant-free survival that significantly deviates from an age- and sex-matched population may benefit from new therapies

Data of an age- and sex-matched population, a population with a life-expectancy comparable with that of other countries participating in the Global PBC Study Group, were retrieved from a Dutch registry (Statistics Netherlands, www.cbs.nl).

The GLOBE score uses age-specific thresholds beyond which survival significantly deviates from an age- and sex matched general population. In subgroups of patients aged 66 years, age-specific GLOBE-score thresholds beyond which survival significantly deviates from matched individuals are 0.52, 0.01, 0.60, 1.01 and 1.69, respectively.