GOtezla – Amgen, Inc.

The GOtezla app offers helpful resources and support you may need during the first 30 days of treatment and beyond with Otezla® (apremilast) 30 mg tablets. Plus, the tracking features make it easy for you to log your symptoms and share any changes with your doctor during office visits.

How GOtezla can help:

• Get personalized information that lets you know what to expect

• Track your progress with photographs, graphs, and notes to show your doctor during office visits

• Treatment reminders to help make sure you don’t miss a dose

• Access to nurses who’ll answer your questions 24 hours a day/7 days a week

GOtezla was developed with the help of people who are currently taking Otezla. When you’re starting treatment, GOtezla puts the tools you need at your fingertips.

APPROVED USES

Otezla® (apremilast) is a prescription medicine approved for the treatment of adult patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

IMPORTANT SAFETY INFORMATION

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of having diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

Otezla is associated with an increase in depression. In clinical studies, some patients reported depression, or suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

Some medicines may make Otezla less effective, and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

Side effects of Otezla include diarrhea, nausea, vomiting, upper respiratory tract infection, runny nose, sneezing, or congestion, abdominal pain, tension headache, and headache. These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed. Otezla has not been studied in pregnant women or in women who are breastfeeding.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

Please see Full Prescribing Information at www.otezla.com/otezla-prescribing-information.pdf.

As a reminder, only you and your doctor can determine what treatment is right for you. This app does not replace any medical advice provided by your healthcare provider. It is important that you discuss your treatment, treatment results, and all side effects with your healthcare provider. This app is not a medical device.

Data rates from your carrier may apply.

This application is brought to you by Amgen and is intended for use by plaque psoriasis and psoriatic arthritis patients, their caregivers, and their healthcare team. The design of this app is owned by Amgen Inc. and is subject to copyright protection. Amgen does not collect personal information from app users except as described in the GOtezla app Privacy Policy.

© 2021 Amgen Inc. All rights reserved.