Hypercholesterolemia

Hypercholesterolemia causes and treatments Cholesterol explained, for cholesterol, LDL HDL cholesterol can be very dangerous. It can lead to various diseases and can eventually kill the patient. Learn how to use this free app how to avoid high cholesterol levels and learn which foods to avoid. Find out how you can avoid ending up with a high cholesterol level or if you already have one know how to take it down. Cures: - What is high cholesterol - what to know about high cholesterol - How to control blood cholesterol - see how your cholesterol - affects cholesterol levels - lowering cholesterol Use Therapeutic Lifestyle Changes - The Different Types of Cholesterol - The Role of LDL or Bad Cholesterol - The Role of HDL or Good Cholesterol - How the Body Produces Cholesterol - Medication to Manage Cholesterol - How to Manage Your Cholesterol

Majority with hypercholesterolemia in the absence of positive family history or secondary cause(s) have polygenic hypercholesterolemia. By contrast, familial hypercholesterolemia (FH) is monogenic disorders affecting the clearance rate of LDL-C from the blood. To date, mutations in four genes (LDLR, APOB, PCSK9, and LDLRAP1) have been identified causing the disorder.

Persons with documented CVD, type 1 or type 2 diabetes, very high levels of individual risk factors (e.g. familial hypercholesterolemia) are automatically at very high or high total CV risk. No risk estimation models are needed for them; they all need active management of all risk factors.

For all other people, the use of a risk estimation system such as SCORE is recommended to estimate total CV risk since many people have several risk factors that, in combination, may result in unexpectedly high levels of total CV risk.